The use of biocatalysts for glycoside bond formation is an attractive strategy in chemical synthesis, but the tight specificity of enzymes can be a significant limitation. An ingenious screening strategy has led to the discovery of a particularly plastic glycosyltransferase.
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Davis, B. Enzymatic glycosynthesis GeTs better. Nat Chem Biol 3, 604–605 (2007). https://doi.org/10.1038/nchembio1007-604
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DOI: https://doi.org/10.1038/nchembio1007-604