Figure 2: Network analysis of GO biological process of giraffe MSA genes.
From: Giraffe genome sequence reveals clues to its unique morphology and physiology
Seventy genes were identified that exhibited MSAs based on amino acid sequence divergence as evaluated by neighbour-joining phylogenetic analysis of mammalian orthologous proteins, enrichment of nonsynonymous substitutions, unique amino acid substitutions at sites otherwise fixed in mammals, substitutions predicted to cause functional changes by Polyphen2 analysis and substitutions under positive selection. Cluster analysis was performed on the set of 70 giraffe MSA genes based on GO Biological Process using Cytoscape 3.0 (ref. 68).
