Table 1 SIV Env reactive mAbs isolated from chronically SIV-infected AGMs.
Ab ID | V H | HCDR 3 (AA) | H Mut (%) | Isotype | V L | LCDR 3 (AA) | L Mut (%) | Sample Type | EC50 (μg ml−1) | Neutralization (IC50, μg ml−1) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
gp120 | V1V2 | V3 | gp140 | sp400 | SIVmacTCLA | SIVsab92018 | |||||||||
DH543 | 5–13 | 12 | 6.6 | G | Vλ1–73 | 11 | 7.1 | Milk | >100 | >100 | >100 | 0 .009 | 0.053 | >50 | >50 |
DH544 | 3–22 | 11 | 8.5 | G | Vλ1–57 | 11 | 5.2 | Milk | >100 | >100 | >100 | 0.005 | 0.087 | >50 | >50 |
DH545 | 4–152 | 9 | 15.6 | G | Vκ2–92 | 9 | 7.5 | Milk | >100 | >100 | >100 | 0.003 | 0.07 | >50 | >50 |
DH546 | 4–152 | 19 | 11.8 | G | Vλ1–73 | 11 | 9.4 | Milk | 0.37 | >100 | >100 | 0.021 | >100 | >50 | >50 |
DH547 | 1–93 | 19 | 11.8 | G | Vλ1–73 | 12 | 4.1 | Milk | 0.054 | >100 | 0.497 | 0.005 | >100 | >50 | >50 |
DH548 | 4–76 | 15 | 12.4 | G | Vλ3–36 | 11 | 5.0 | Blood | 0.004 | >100 | >100 | <0.001 | >100 | >50 | >50 |
DH549 | 3–67 | 13 | 5.9 | G | Vκ1–NL2 | 9 | 6.1 | Blood | 0.001 | >100 | >100 | 0.002 | >100 | <0.02 | >50 |
DH550 | 3–67 | 12 | 12.5 | G | Vκ3–53 | 9 | 4.2 | Blood | 0.002 | >100 | >100 | 0.002 | >100 | >50 | >50 |
DH551 | 4–88 | 19 | 13.2 | G | Vκ1–39 | 9 | 3.8 | Blood | 0.004 | >100 | 2.229 | 0.003 | >100 | <0.02 | >50 |
DH552 | 4–88 | 17 | 7.3 | G | Vλ1–73 | 11 | 2.6 | Blood | 5.899 | >100 | >100 | 0.397 | >100 | >50 | >50 |
