Figure 1: Proteobacterial proteins related to Streptomyces ARG proteins.
From: Dissemination of antibiotic resistance genes from antibiotic producers to pathogens
Relationships between all experimentally validated Streptomyces ARG proteins and their most similar homologues in proteobacteria were analysed by phylogenetic analysis (Supplementary Fig. 1). Selected pairs that might be connected via interphylum HGT are summarized here, with the proposed transfer direction indicated by an arrow. Protein sequence identity was determined by BLASTP. aThe proteins were BLASTed against pathogen genome database PATRIC to see if they have close homologues (sequence identity threshold of 90%) in pathogens.
