Table 1 ELT screening progression.

From: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Phase

S. aureus

A. baumannii

M. tuberculosis

Ligandability assessment

 Initial number of targets considered

39

80

42

 Targets amenable to ELT selection

32

70

41

 Targets with ELT signal

14

52

27

Binding confirmation

 Targets with off-DNA synthesis

14

18

13

 Targets with confirmed active chemical series (IC50 and/or MIC)

7

17

4*

 Targets with confirmed MoA

2

3

ND

  1. ND, not determined.
  2. The table shows a summary of the progression of protein targets through each tractability panel. For additional detail and a full list of targets prosecuted, see Supplementary Table 1.
  3. *Off-DNA activity assessment ongoing for remaining nine targets.
Back to article page