Figure 1: Sequence alignment of the NavMs pore construct and the equivalent region of NavAb.
From: Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
Alignments are based on their respective crystal structures, with coloured boxes indicating the locations of the S5 and S6 transmembrane segments (magenta and blue, respectively), the turret loop (cyan), the P1- and P2-helix regions (green and yellow, respectively), the SF (red) and the beginning of the C-terminal domain (the latter, with residue names indicated in grey, is not visible in either of the crystal structures). The black underlined region indicates where the deviation between the S6 helices in the open and closed forms occurs.
