Figure 4: Linker movement required to open the pore.
From: Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
Overlay showing the residues (in space-filling representation) involved in potential clashes at the end of the open NavMs (red) with those in the S4–S5 linker hinge region (yellow) of the closed NavAb form (blue). This suggests that in the open form of the full-length NavMs channel, the N-terminal end of S5 and the linker must be in a slightly different position from that present in the NavAb closed structure.
