Figure 7: Model suggesting how the formation of a single procentriole per each parental centriole is controlled. | Nature Communications

Figure 7: Model suggesting how the formation of a single procentriole per each parental centriole is controlled.

From: Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

Figure 7

Direct association of STIL with Plk4 and STIL phosphorylation by Plk4 occur at the onset of centriole formation. Phosphorylated STIL directly binds to HsSAS-6, which leads to centriolar loading of HsSAS-6 for cartwheel assembly. Centriolar loading of the STIL/HsSAS-6 complex limits centriolar distribution of Plk4 to one site per each parental centriole. This coordinated action could ensure formation of a single procentriole per each parental centriole and, concurrently, inhibit formation of another procentriole.

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