Abstract
In an effort to improve the outcome of hypospadias repair, Kaya et al. performed a prospective, randomized study of transdermal dihydrotestosterone (DHT) gel as a preoperative adjunct to surgery. They found that patients who received DHT gel had fewer complications and better cosmesis than patients who underwent surgery alone. The authors attribute the differences between the two groups to an increased blood flow produced by the gel. The series of patients was small, and a larger sample size might have produced different results. Some of the outcomes measured were subjective, and the methods used to assess these outcomes were not clear. If a larger study confirms the results obtained by Kaya and colleagues, transdermal DHT gel might prove to be a valuable adjunct to hypospadias surgery.
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References
Jacobs SC et al. (1975) Topical testosterone therapy for penile growth. Urology 6: 708–710
Koff SA and Jayanthi VR (1999) Preoperative treatment with human chorionic gonadotropin in infancy decreases the severity of proximal hypospadias and chordee. J Urol 162: 1435–1439
Hensle TW et al. (2001) Hypospadias repair in adults: adventures and misadventures. J Urol 165: 77–79
Kaya C et al. (2008) The efficacy of dihydrotestosterone transdermal gel before primary hypospadias surgery: a prospective, controlled, randomized study. J Urol 179: 684–688
Snodgrass W (1994) Tubularized, incised plate urethroplasty for distal hypospadias. J Urol 151: 464–465
Mureau MA et al. (1995) Psychosexual adjustment of children and adolescents after different types of hypospadias surgery: a norm-related study. J Urol 154: 1902–1907
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Kaplan, G. Does administration of transdermal dihydrotestosterone gel before hypospadias repair improve postoperative outcomes?. Nat Rev Urol 5, 474–475 (2008). https://doi.org/10.1038/ncpuro1178
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DOI: https://doi.org/10.1038/ncpuro1178