The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.
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References
Knutson, S.K. et al. Nat. Chem. Biol. 8, 890–896 (2012).
McCabe, M.T. et al. Nature 492, 108–112 (2012).
Bernt, K.M. et al. Cancer Cell 20, 66–78 (2011).
Jaffe, J.D. et al. Nat. Genet. 45, 1386–1391 (2013).
Barretina, J. et al. Nature 483, 603–607 (2012).
Yap, D.B. et al. Blood 117, 2451–2459 (2011).
Ernst, T. et al. Nat. Genet. 42, 722–726 (2010).
Yuan, W. et al. J. Biol. Chem. 286, 7983–7989 (2011).
Martinez-Garcia, E. et al. Blood 117, 211–220 (2011).
Kuo, A.J. et al. Mol. Cell 44, 609–620 (2011).
Shen, X. et al. Mol. Cell 32, 491–502 (2008).
Loh, M.L. & Mullighan, C.G. Clin. Cancer Res. 18, 2754–2767 (2012).
Shurtleff, S.A. et al. Leukemia 9, 1985–1989 (1995).
Jaju, R.J. et al. Blood 98, 1264–1267 (2001).
Rosati, R. et al. Blood 99, 3857–3860 (2002).
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LaFave, L., Levine, R. Mining the epigenetic landscape in ALL. Nat Genet 45, 1269–1270 (2013). https://doi.org/10.1038/ng.2808
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DOI: https://doi.org/10.1038/ng.2808