Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important implications for the understanding of imprinted gene networks.
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Change history
13 June 2014
In the version of this article initially published, the following sentence on page 529 referred to an incorrect locus (in bold): "In mice, the lncRNA Kcnq1ot1 associates with G9a and the polycomb repressive complex 2 (PRC2) to regulate the expression of other genes in the Dlk1-Dio3 locus in cis." The correct locus is Kcnq1. The error has been corrected in the HTML and PDF versions of the article.
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Murrell, A. Cross-talk between imprinted loci in Prader-Willi syndrome. Nat Genet 46, 528–530 (2014). https://doi.org/10.1038/ng.2994
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DOI: https://doi.org/10.1038/ng.2994
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Corrigendum: Cross-talk between imprinted loci in Prader-Willi syndrome
Nature Genetics (2014)