The restriction of herpesvirus by natural killer cells, initiated before the acquired immune response, illustrates the value of innate immune mechanisms for viral containment. Now, a new study shows that the activating natural killer cell receptor Ly49P and the major histocompatibility complex class I H-2Dk molecule act in concert to restrict mouse cytomegalovirus infection, identifying a new mechanism of host resistance.
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Carrington, M. Antiviral synergism. Nat Genet 37, 565–566 (2005). https://doi.org/10.1038/ng0605-565
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DOI: https://doi.org/10.1038/ng0605-565