Adult mammalian tissues are maintained by multipotent stem cells, many of which are highly responsive to soluble Wnt proteins. A new study reports the requirement of two Tcf family members, Tcf3 and Tcf4, in the development and maintenance of epithelial stem cells in skin through Wnt-dependent and -independent processes.
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References
Nguyen, H. et al., Nat. Genet. 41, 1068–1075, 2009.
Fuchs, E. Nature 445, 834–842 (2007).
Yan, X. & Owens, D.M. Stem Cell Rev. 4, 113–118 (2008).
Angers, S. & Moon, R.T. Nat. Rev. Mol. Cell Biol. 10, 468–477 (2009).
Reya, T. & Clevers, H. Nature 434, 843–850 (2005).
Cotsarelis, G., Sun, T.T. & Lavker, R.M. Cell 61, 1329–1337 (1990).
Trempus, C.S. et al. J. Invest. Dermatol. 120, 501–511 (2003).
Blanpain, C. et al. Cell 118, 635–648 (2004).
Nguyen, H., Rendl, M. & Fuchs, E. Cell 127, 171–183 (2006).
Huelsken, J. et al. Cell 105, 533–545 (2001).
Andl, T. et al. Dev. Cell 2, 643–653 (2002).
Gat, U. et al. Cell 95, 605–614 (1998).
Ito, M. et al. Nature 447, 316–320 (2007).
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Owens, D. Tcf proteins are deeply rooted in skin. Nat Genet 41, 1050–1051 (2009). https://doi.org/10.1038/ng1009-1050
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DOI: https://doi.org/10.1038/ng1009-1050