Mutations in the gene encoding the transcription factor GATA1 contribute to a specific type of leukemia in people with Down syndrome. This finding suggests a multistep pathway of leukemia development that involves GATA1 and one or more genes on chromosome 21.
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Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia
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Look, A. A leukemogenic twist for GATA1. Nat Genet 32, 83–84 (2002). https://doi.org/10.1038/ng960
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DOI: https://doi.org/10.1038/ng960
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