Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Sox2 as a servant of two masters

Nature Immunology volume 16, pages 335–336 (2015)Cite this article

Subjects

The transcription factor Sox2 has an additional function in neutrophils, as a cytoplasmic sensor of DNA. Upon binding bacterial DNA, Sox2 initiates a signaling cascade dependent on the kinase TAK1 and adaptor TAB2 that culminates in the expression of genes encoding pro-inflammatory molecules.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Sensors of dsDNA in macrophages and neutrophils.

Katie Vicari/Nature Publishing Group

References

  1. Wu, J. & Chen, Z.J. Annu. Rev. Immunol. 32, 461–488 (2014).

    Article  CAS  Google Scholar 

  2. Xia, P. et al. Nat. Immunol. 16, 366–375 (2015).

    Article  CAS  Google Scholar 

  3. Sarkar, A. & Hochedlinger, K. Cell Stem Cell 12, 15–30 (2013).

    Article  CAS  Google Scholar 

  4. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  5. Kamachi, Y. & Kondoh, H. Development 140, 4129–4144 (2013).

    Article  CAS  Google Scholar 

  6. Chen, Z.J. Immunol. Rev. 246, 95–106 (2012).

    Article  Google Scholar 

  7. Hornung, V. & Latz, E. Nat. Rev. Immunol. 10, 123–130 (2010).

    Article  CAS  Google Scholar 

  8. Hornung, V., Hartmann, R., Ablasser, A. & Hopfner, K.P. Nat. Rev. Immunol. 14, 521–528 (2014).

    Article  CAS  Google Scholar 

  9. Abe, T. & Barber, G.N. J. Virol. 88, 5328–5341 (2014).

    Article  Google Scholar 

  10. Yanai, H., Ban, T. & Taniguchi, T. Trends Immunol. 33, 633–640 (2012).

    Article  CAS  Google Scholar 

  11. Bianchi, M.E. & Manfredi, A.A. Immunol. Rev. 220, 35–46 (2007).

    Article  CAS  Google Scholar 

  12. Yasuhara, N. et al. Nat. Cell Biol. 9, 72–79 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Arun K. Mankan and Veit Hornung are at the Institute of Molecular Medicine, University Hospital, University of Bonn, Bonn, Germany.,

    Arun K Mankan & Veit Hornung

Authors
  1. Arun K Mankan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Veit Hornung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Veit Hornung.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mankan, A., Hornung, V. Sox2 as a servant of two masters. Nat Immunol 16, 335–336 (2015). https://doi.org/10.1038/ni.3121

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3121

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing