New findings show that the NLRP3 inflammasome is inactivated by disassembly of the inflammasome mediated by the kinase PKA and that this regulation might be negated in NLRP3-gain-of-function diseases.
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Swanson, K., Ting, JY. Reining in uncontrolled inflammasome with PKA. Nat Immunol 17, 1137–1138 (2016). https://doi.org/10.1038/ni.3556
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DOI: https://doi.org/10.1038/ni.3556