'Forward' genetic approaches for elucidating function can lead to unexpected findings. A single missense mutation is found to disrupt both antigen presentation and nucleic acid Toll-like receptor signaling, two processes involving endocytic pathways.
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Katie Ris
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This is publication number 116 from The Edward Jenner Institute for Vaccine Research.
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Carter, R., Tough, D. '3d' effects on global immunity. Nat Immunol 7, 127–128 (2006). https://doi.org/10.1038/ni0206-127
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DOI: https://doi.org/10.1038/ni0206-127
