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Microbial killing: hold the bleach and pass the salt!

Nature Immunology volume 3, pages 340–342 (2002)Cite this article

The current paradigm is that reactive oxygen species produced by leukocytes directly kill bacteria. Data in a recent Nature article belie that simplicity.

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Figure 1: A fresh look at phagocytic killing.

References

  1. Reeves, E. P. et al. Nature 416, 291–297 (2002).

    Article  CAS  Google Scholar 

  2. Dinauer, M. C., Nauseef, W. M. & Newburger, P. E. in The Metabolic and Molecular Basis of Inherited Diseases (eds Scriver, C. R. et al.), Ch. 133 (McGraw-Hill, New York, 2000).

    Google Scholar 

  3. Hampton, M. B., Kettle, A. J. & Winterbourn, C. C. Infect. Immun. 64, 3512–3517 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Aratani, Y. et al. Infect. Immun. 67, 1828–1836 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Nanda, A., Curnutte, J. T. & Grinstein, S. J. Clin. Invest. 93, 1770–1775 (1994).

    Article  CAS  Google Scholar 

  6. Henderson, L. M., Chappell, J. B. & Jones, O. T. Biochem. J. 246, 325–329 (1987).

    Article  CAS  Google Scholar 

  7. Kolset, S. O. & Gallagher, J. T. Biochim. Biophys. Acta 1032, 191–211 (1990).

    CAS  PubMed  Google Scholar 

  8. Rausch, P. G. & Moore, T. G. Blood 46, 913–919 (1975).

    CAS  PubMed  Google Scholar 

  9. Tkalcevic, J., et al. J. Immunity 12, 201–210 (2000).

    Article  CAS  Google Scholar 

  10. Donnenberg, M. S. Nature 406 768–774 (2000).

    Article  CAS  Google Scholar 

  11. Henderson, L. M. & Meech, R. W. J. Gen. Physiol. 114, 771–786 (1999).

    Article  CAS  Google Scholar 

  12. Diebold, B. A. & Bokoch, G. M. Nature Immunol. 2, 211–215 (2001).

    Article  CAS  Google Scholar 

Download references

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  1. The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA

    Gary M. Bokoch

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  1. Gary M. Bokoch
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Bokoch, G. Microbial killing: hold the bleach and pass the salt!. Nat Immunol 3, 340–342 (2002). https://doi.org/10.1038/ni0402-340

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