Terminal B cell differentiation requires a massive increase in the biosynthetic capacity to synthesize antibodies in response to infection. New data shows the ER stress response activates and commits B cells to this robust metabolic state.
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Ma, Y., Hendershot, L. The stressful road to antibody secretion. Nat Immunol 4, 310–311 (2003). https://doi.org/10.1038/ni0403-310
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DOI: https://doi.org/10.1038/ni0403-310
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