To prevent RNA virus–dependent tissue damage caused by interferon-regulatory factor 3 (IRF3)–induced type I interferons, proteasome-dependent destruction of IRF3 is orchestrated by the cytoplasmic prolyl isomerase Pin1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kawai, T. & Akira, S. Nat. Immunol. 7, 131–137 (2006).
Thanos, D. & Maniatis, T. Cell 83, 1091–1100 (1995).
Rothenfusser, S. et al. J. Immunol. 175, 5260–5268 (2005).
Yoneyama, M. et al. J. Immunol. 175, 2851–2858 (2005).
Saitoh, T. et al. Nat. Immunol. 7, 598–605 (2006).
Fitzgerald, K.A. et al. Nat. Immunol. 4, 491–496 (2003).
Sharma, S. et al. Science 300, 1148–1151 (2003).
Lin, R., Heylbroeck, C., Pitha, P.M. & Hiscott, J. Mol. Cell. Biol. 18, 2986–2996 (1998).
Wulf, G., Finn, G., Suizu, F. & Lu, K.P. Nat. Cell Biol. 7, 435–441 (2005).
Obata, Y. et al. J. Biol. Chem. 280, 18355–18360 (2005).
Wulf, G.M. et al. EMBO J. 20, 3459–3472 (2001).
Ryo, A. et al. Mol. Cell 12, 1413–1426 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goutagny, N., Severa, M. & Fitzgerald, K. Pin-ning down immune responses to RNA viruses. Nat Immunol 7, 555–557 (2006). https://doi.org/10.1038/ni0606-555
Issue Date:
DOI: https://doi.org/10.1038/ni0606-555