Members of the PIAS family can negatively regulate the cytokine-activated Jak-STAT pathway in vitro. One member of this family, PIAS1, is a nonredundant and physiologic regulator of certain STAT1-dependent interferon-induced genes.
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O'Shea, J., Watford, W. A peek at PIAS. Nat Immunol 5, 875–876 (2004). https://doi.org/10.1038/ni0904-875
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DOI: https://doi.org/10.1038/ni0904-875
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