Despite considerable advances in identifying the environmental agents that trigger allergy and the immunological mechanisms involved, progress in developing effective treatments remains frustratingly slow. Is it time to rethink some of the paradigms guiding this research?
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References
Ziska, L.H. et al. J. Allergy Clin. Immunol. 111, 290–295 (2003).
Asero, R. J. Investig. Allergol. Clin. Immunol. 14, 208–213 (2004).
Rottem, M., Szyper-Kravitz, M. & Shoenfeld, Y. Int. Arch. Allergy Immunol. 136, 198–204 (2005).
Hjern, A., Rasmussen, F. & Hedlin, G. Pediatr. Allergy Immunol. 10, 101–106 (1999).
Björkstén, F. & Suoniemi . Acta Med. Scand. 209, 299–303 (1981).
Holt, P.G., Macaubas, C., Stumbles, P.A. & Sly, P.D. Nature 402, B12–B17 (1999).
Thornton, C.A. et al. J. Immunol. 173, 3084–3092 (2004).
Gavin, M.A. & Bevan, M.J. Immunity 3, 793–800 (1995).
Lauener, R.P. et al. Lancet 360, 465–466 (2002).
Peat, J.K. et al. J. Allergy Clin. Immunol. 114, 807–813 (2004).
Woodcock, A. et al. Am. J. Respir. Crit. Care Med. 170, 433–439 (2004).
Constant, S., Pfeiffer, C., Woodard, A., Pasqualini, T. & Bottomly, K. J. Exp. Med. 182, 1591–1596 (1995).
Rogers, P.R. & Croft, M. J. Immunol. 163, 1205–1213 (1999).
Platts-Mills, T., Vaughan, J., Squillace, S., Woodfolk, J. & Sporik, R. Lancet 357, 752–756 (2001).
Cullinan, P. et al. Thorax 59, 855–861 (2004).
Holt, P.G. & Sedgwick, J.D. Immunol. Today 8, 14–15 (1987).
Sedgwick, J.D. & Holt, P.G. Immunology 56, 635–642 (1985).
Heaton, T. et al. Lancet 365, 142–149 (2005).
O'Sullivan, S. et al. Am. J. Respir. Crit. Care Med. 164, 560–564 (2001).
Rowe, J. et al. J. Allergy Clin. Immunol. 113, 710–716 (2004).
Seneviratne, S.L. et al. J. Clin. Invest. 110, 1283–1291 (2002).
Grewe, M. et al. Immunol. Today 19, 359–361 (1998).
Niederberger, V. et al. J. Allergy Clin. Immunol. 102, 579–591 (1998).
Niederberger, V. et al. J. Invest. Dermatol. 117, 848–851 (2001).
Trombone, A.P. et al. Clin. Exp. Allergy 32, 1323–1328 (2002).
Mark, P.G., Segal, D.B., Dallaire, M.L. & Garman, R.D. Clin. Exp. Allergy 26, 1316–1328 (1996).
Satinover, S.M. et al. J. Allergy Clin. Immunol. 115, 803–809 (2005).
Chapman, M.D., Rowntree, S., Mitchell, E.B., Di Prisco de Fuenmajor, M.C. & Platts-Mills, T.A. J. Allergy Clin. Immunol. 72, 27–33 (1983).
Epton, M.J. et al. Clin. Exp. Allergy 32, 1341–1347 (2002).
Thomas, W., Hales, B. & Smith, W. Curr. Allergy Asthma Rep. 5, 388–393 (2005).
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Holt, P., Thomas, W. Sensitization to airborne environmental allergens: unresolved issues. Nat Immunol 6, 957–960 (2005). https://doi.org/10.1038/ni1005-957
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DOI: https://doi.org/10.1038/ni1005-957
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