IAPP, a hormone secreted together with insulin and deposited in pancreatic islets in type 2 diabetes, can induce macrophage processing of interleukin 1 linked to beta-cell destruction in type 2 diabetes.
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Change history
21 October 2010
In the version of this article initially published, some of the text on p 882 was inaccurate. The correct text should read as follows: “thereby counteracting the beneficial effects of blocking IAPP on islet inflammation” (middle column) and “This mechanism has been suggested to mediate ROS-dependent inflammasome activation induced by high concentrations of glucose in mouse pancreatic beta cells12, although this finding is now being debated” (right column, first full paragraph, second sentence). The errors have been corrected in the HTML and PDF versions of the article.
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T.M.-P. is a part-time employee of and owns shares in Novo Nordisk.
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Mandrup-Poulsen, T. IAPP boosts islet macrophage IL-1 in type 2 diabetes. Nat Immunol 11, 881–883 (2010). https://doi.org/10.1038/ni1010-881
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DOI: https://doi.org/10.1038/ni1010-881
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