A pathway has been defined linking cell cycle inhibitor p27Kip1 to the inhibition of cyclin-dependent kinase 2 and its phosphorylation of transcription factor Smad3 in the induction of in vivo tolerance.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schwartz, R.H. Annu. Rev. Immunol. 21, 305–334 (2003).
Li, L., Iwamoto, Y., Berezovskaya, A. & Boussiotis, V.A. Nat. Immunol. 7, 1157–1165 (2006).
Liu, Y.C. Annu. Rev. Immunol. 22, 81–127 (2004).
Powell, J.D., Lerner, C.G. & Schwartz, R.H. J. Immunol. 162, 2775–2784 (1999).
Boussiotis, V.A. et al. Nat. Med. 6, 290–297 (2000).
Sherr, C.J. Science 274, 1672–1677 (1996).
Rowell, E.A. et al. J. Immunol. 175, 3359–3368 (2005).
Tzachanis, D. et al. Nat. Immunol. 2, 1174–1182 (2001).
Appleman, L.J., Berezovskaya, A., Grass, I. & Boussiotis, V.A. J. Immunol. 164, 144–151 (2000).
Colombetti, S., Benigni, F., Basso, V. & Mondino, A. J. Immunol. 169, 6178–6186 (2002).
McKarns, S.C., Schwartz, R.H. & Kaminski, N.E. J. Immunol. 172, 4275–4284 (2004).
Wolfraim, L.A. et al. N. Engl. J. Med. 351, 552–559 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rudd, C. Cell cycle 'check points' T cell anergy. Nat Immunol 7, 1130–1132 (2006). https://doi.org/10.1038/ni1106-1130
Issue Date:
DOI: https://doi.org/10.1038/ni1106-1130
This article is cited by
-
Mechanismen immunologischer Toleranz und ihrer Dysregulation bei rheumatischen Erkrankungen
Zeitschrift für Rheumatologie (2023)
-
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
Nature (2019)
-
Cell cycle and immune-related processes are significantly altered in chronic GVHD
Bone Marrow Transplantation (2008)