Understanding of the signaling networks regulating T cell anergy remains incomplete. Two reports now demonstrate that alterations in diacylglycerol metabolism regulate the adoption of an anergic versus an activated T cell fate.
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Mueller, D. Linking diacylglycerol kinase to T cell anergy. Nat Immunol 7, 1132–1134 (2006). https://doi.org/10.1038/ni1106-1132
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DOI: https://doi.org/10.1038/ni1106-1132