Cell-mediated activation of latent TGF-β1 is a key promoting event in fibrosis in all organs. A new study shows that specific targeting of the αv subunit of integrins in fibrogenic myofibroblasts effectively reduces developing and established fibrosis in liver, kidneys and lungs (pages 1617–1624).
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Hinz, B. It has to be the αv: myofibroblast integrins activate latent TGF-β1. Nat Med 19, 1567–1568 (2013). https://doi.org/10.1038/nm.3421
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DOI: https://doi.org/10.1038/nm.3421
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