Depression is mechanistically not well understood. A new study investigates the expression of chromatin-remodeling complexes in a mouse model for depression and describes an epigenetic pathway that may explain why some individuals are more susceptible to stress-induced depression than others.
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Sananbenesi, F., Fischer, A. Remodeling the susceptibility to stress-induced depression. Nat Med 21, 1125–1126 (2015). https://doi.org/10.1038/nm.3970
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DOI: https://doi.org/10.1038/nm.3970