Antagonists of the αvβ3 and αvβ5 integrins inhibit angiogenesis in cancer, arthritis and ischemic retinopathy. However, a surprising new report suggests that knockout mice lacking β3 and/or β5 integrins show enhanced, rather than reduced angiogenesis. (pages 27–34)
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References
Hynes, R.O. Cell adhesion: old and new questions. Trends Cell Biol. 9, M33–37 (1999).
Giancotti, F.G. & Ruoslahti, E. Integrin signaling. Science 285, 1028–1032 (1999).
Eliceiri, B.P. & Cheresh, D.A. Adhesion events in angiogenesis. Curr. Opin. Cell Biol. 13, 563–568 (2001).
Rupp, P.A. & Little, C.D. Integrins in vascular development. Circ. Res. 89, 566–572 (2001).
Carmeliet, P. & Jain, R.K. Angiogenesis in cancer and other diseases. Nature 407, 249–257 (2000).
Reynolds, L.E. et al. Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins. Nature Med 8, 27–34 (2002).
Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435–439 (1996).
Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nature Med. 6, 389–395 (2000).
Bouvard, D. et al. Functional consequences of integrin gene mutations in mice. Circ. Res. 89, 211–223 (2001).
Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nature Med. 7, 575–583 (2001).
Diaz-Gonzalez, F., Forsyth, J., Steiner, B. & Ginsberg, M.H. Trans-dominant inhibition of integrin function. Mol. Biol. Cell 7, 1939–1951 (1996).
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Carmeliet, P. Integrin indecision. Nat Med 8, 14–16 (2002). https://doi.org/10.1038/nm0102-14
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DOI: https://doi.org/10.1038/nm0102-14
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