Signaling through costimulatory receptors classically occurs in cells of the immune system. Now the distinction between immune cells and osteoclasts, bone resorbing cells, begins to blur. Osteoclasts need costimulatory signals too.
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Baron, R. Arming the osteoclast. Nat Med 10, 458–460 (2004). https://doi.org/10.1038/nm0504-458
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DOI: https://doi.org/10.1038/nm0504-458
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