Autoimmunity develops when one's own immune cells and pathogenic antibodies react against the body, causing inflammation, degeneration, tissue destruction and even organ failure. But autoimmunity mediators can also evoke other pathological side effects, and individual factors can worsen the morbidity of the people suffering from autoimmune disorders, adding another level of complexity to these diseases. In 'Bedside to Bench', Mark Anderson and Michael Waterfield peruse a potential link between immunodeficiency and autoimmunity. Autoantibodies against cytokines involved in tackling Candida albicans infection may underlie the trait of increased susceptibility to yeast observed in people with such autoantibodies. In 'Bench to Bedside', Daniel Cua and Jonathan Sherlock discuss how the immune response induced by gut microbiota may be responsible for autoimmune attacks at distant sites, such as the joints.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Goyal, R., Bulua, A.C., Nikolov, N.P., Schwartzberg, P.L. & Siegel, R.M. Curr. Opin. Rheumatol. 21, 78–84 (2009).
Hönig, M. & Schwarz, K. Curr. Opin. Rheumatol. 18, 383–388 (2006).
Khiong, K. et al. J. Clin. Invest. 117, 1270–1281 (2007).
Perheentupa, J. J. Clin. Endocrinol. Metab. 91, 2843–2850 (2006).
Nagamine, K. et al. Nat. Genet. 17, 393–398 (1997).
Finnish-German APECED Consortium. Nat. Genet. 17, 399–403 (1997).
Anderson, M.S. et al. Science 298, 1395–1401 (2002).
Mathis, D. & Benoist, C. Annu. Rev. Immunol. 27, 287–312 (2009).
Matsumoto, M. Eur. J. Immunol. 41, 12–17 (2011).
Gardner, J.M. et al. Science 321, 843–847 (2008).
Kisand, K. et al. J. Exp. Med. 207, 299–308 (2010).
Puel, A. et al. J. Exp. Med. 207, 291–297 (2010).
Meager, A. et al. PLoS Med. 3, e289 (2006).
Conti, H.R. et al. J. Exp. Med. 206, 299–311 (2009).
Puel, A. et al. Science 332, 65–68 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Waterfield, M., Anderson, M. Autoimmunity's collateral damage: Immunodeficiency hints at autoreactivity to cytokines. Nat Med 17, 1054–1055 (2011). https://doi.org/10.1038/nm0911-1054
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0911-1054