Supplementary Figure 3: Procedure used to infer the biological significance of QSs.
From: PDB-wide identification of biological assemblies from conserved quaternary structure geometry
Each symmetry group is considered iteratively. Within each group, each QS is used to search for structural homologs. If a homologue is found, both QSs are annotated to be “correct.” Once all the QSs of a symmetry group have been processed, each QS is used again to search for proteins identical in sequence but having different QSs. If found, we considered such QSs to be likely non-biological and annotated them as such.
