Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Parasite pathogenesis: The dynamics of chronic malaria

Nature Microbiology volume 2, Article number: 17039 (2017) Cite this article

Subjects

Rodent malaria parasites establish chronic infections through the sequential expression of subsets of variant antigen-encoding genes, a process that surprisingly appears to be independent of adaptive immunity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Infection of laboratory mice with P. chabaudi malaria parasites results in chronic infection.

References

  1. Deitsch, K. W., Lukehart, S. A. & Stringer, J. R. Nat. Rev. Microbiol. 7, 493–503 (2009).

    Article  CAS  Google Scholar 

  2. Brugat, T. et al. Nat. Microbiol. 2, 16276 (2017).

    Article  CAS  Google Scholar 

  3. Bachmann, A. et al. PLoS Pathog. 12, e1005538 (2016).

    Article  Google Scholar 

  4. Peters, J. et al. Proc. Natl Acad. Sci. USA 99, 10689–10694 (2002).

    Article  CAS  Google Scholar 

  5. Wang, C. W. et al. Parasitol. Int. 58, 478–480 (2009).

    Article  CAS  Google Scholar 

  6. Bousema, T. et al. Nat. Rev. Micro. 12, 833–840 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kirk Deitsch is in the Department of Microbiology and Immunology, Weill Cornell Medical College, New York New York 10065, USA.,

    Kirk W. Deitsch

Authors
  1. Kirk W. Deitsch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kirk W. Deitsch.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Deitsch, K. Parasite pathogenesis: The dynamics of chronic malaria. Nat Microbiol 2, 17039 (2017). https://doi.org/10.1038/nmicrobiol.2017.39

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/nmicrobiol.2017.39

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing