By bringing mGluR1/5 and proline-directed kinases together, the scaffold protein Preso1 stabilizes the interaction between mGluR1/5 and Homer. This mechanism may attenuate calcium influx into spinal neurons and reduce pain.
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Radulovic, J., Tronson, N. Preso1, mGluR5 and the machinery of pain. Nat Neurosci 15, 805–807 (2012). https://doi.org/10.1038/nn.3118
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DOI: https://doi.org/10.1038/nn.3118