Conclusive evidence for defective neurodevelopment in schizophrenia is lacking. Two DNA methylation studies now draw a link between fetal brain epigenomes, epigenetic alterations in the adult diseased brain and genetic risk for the disease.
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References
Jaffe, A.E. et al. Nat. Neurosci. 19, 40–47 (2016).
Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature 511, 421–427 (2014).
Hannon, E. et al. Nat. Neurosci. 19, 48–54 (2016).
Roussos, P. et al. Cell Reports 9, 1417–1429 (2014).
De Jager, P.L. et al. Nat. Neurosci. 17, 1156–1163 (2014).
Huynh, J.L. et al. Nat. Neurosci. 17, 121–130 (2014).
Iwamoto, K. et al. Genome Res. 21, 688–696 (2011).
Lister, R. et al. Science 341, 1237905 (2013).
Cheung, I. et al. Proc. Natl. Acad. Sci. USA 107, 8824–8829 (2010).
Mo, A. et al. Neuron 86, 1369–1384 (2015).
Maze, I. et al. Neuron 87, 77–94 (2015).
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Sharp, A., Akbarian, S. Back to the past in schizophrenia genomics. Nat Neurosci 19, 1–2 (2016). https://doi.org/10.1038/nn.4203
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DOI: https://doi.org/10.1038/nn.4203
