Many people still associate brain glucose metabolism with neurons. A new report shows that stimulation of astrocytic glutamate uptake increases glucose utilization, suggesting that astrocytes play a major role in the glucose uptake signal. However, this still reflects synaptic activity.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease
npj Parkinson's Disease Open Access 13 July 2023
-
Effect of the identification group size and image resolution on the diagnostic performance of metabolic Alzheimer’s disease-related pattern
EJNMMI Research Open Access 24 May 2023
-
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
European Journal of Nuclear Medicine and Molecular Imaging Open Access 18 July 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Reivich, M. et al. Acta Neurol. Scand. (suppl.) 64, 190–191 (1977).
Kuhl, D.E., Phelps, M.E., Hoffman, E.J., Robinson, G.D. Jr. & MacDonald, N.S. Acta Neurol. Scand. (suppl.) 64, 192–193 (1977).
Zimmer, E.R. et al. Nat. Neurosci. 20, 393–395 (2017).
Voutsinos-Porche, B. et al. Neuron 37, 275–286 (2003).
Magistretti, P.J. & Allaman, I. Neuron 86, 883–901 (2015).
Pellerin, L. & Magistretti, P.J. Proc. Natl. Acad. Sci. USA 91, 10625–10629 (1994).
Schöll, M. et al. Sci. Rep. 5, 16404 (2015).
Hefendehl, J.K. et al. Nat. Commun. 7, 13441 (2016).
Brendel, M. et al. J. Nucl. Med. 57, 954–960 (2016).
Backes, H. et al. Neuroimage 128, 54–62 (2016).
Fan, Z., Okello, A.A., Brooks, D.J. & Edison, P. Brain 138, 3685–3698 (2015).
Niethammer, M. & Eidelberg, D. Ann. Neurol. 72, 635–647 (2012).
Hirano, S. et al. J. Neurosci. 28, 4201–4209 (2008).
Shao, W. et al. Nature 494, 90–94 (2013).
Lundgaard, I. et al. Nat. Commun. 6, 6807 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Stoessl, A. Glucose utilization: still in the synapse. Nat Neurosci 20, 382–384 (2017). https://doi.org/10.1038/nn.4513
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.4513
This article is cited by
-
Effect of the identification group size and image resolution on the diagnostic performance of metabolic Alzheimer’s disease-related pattern
EJNMMI Research (2023)
-
Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease
npj Parkinson's Disease (2023)
-
Functional brain networks in the evaluation of patients with neurodegenerative disorders
Nature Reviews Neurology (2023)
-
Identification and validation of Alzheimer’s disease-related metabolic brain pattern in biomarker confirmed Alzheimer’s dementia patients
Scientific Reports (2022)
-
Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study
Molecular Neurobiology (2022)