Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

How I learned to stop worrying and love calcineurin

Many kinases have been implicated in memory formation, but a new study suggests that a phosphatase, calcineurin, is important for the long-lasting nature of emotional memories by making them resistant to extinction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The role of calcineurin in conditioned taste aversion.

Katie Ris-Vicari

References

  1. Baumgärtel, K. et al. Nat. Neurosci. 11, 572–578 (2008).

    Article  PubMed  Google Scholar 

  2. Garcia, J., Kimeldorf, D.J. & Koelling, R.A. Science 122, 157–158 (1955).

    CAS  PubMed  Google Scholar 

  3. Welzl, H., D'Adamo, P. & Lipp, H.P. Behav. Brain Res. 125, 205–213 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. Yamamoto, T., Shimura, T., Sako, N., Yasoshima, Y. & Sakai, N. Behav. Brain Res. 65, 123–137 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Havekes, R., Nijholt, I.M., Visser, A.K., Eisel, U.L. & Van der Zee, E.A. Neurobiol. Learn. Mem. published online, doi:10.1016/j.nlm.2007.08.003 (18 September 2007).

  6. Lin, C.H. et al. J. Neurosci. 23, 1574–1579 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lamprecht, R., Hazvi, S. & Dudai, Y. J. Neurosci. 17, 8443–8450 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Barad, M., Gean, P.W. & Lutz, B. Biol. Psychiatry 60, 322–328 (2006).

    Article  PubMed  Google Scholar 

  9. Stafstrom-Davis, C.A. et al. Learn. Mem. 8, 272–278 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Winder, D.G. & Sweatt, J.D. Nat. Rev. Neurosci. 2, 461–474 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Kim, J. et al. Proc. Natl. Acad. Sci. USA 104, 20955–20960 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sindreu, C., Storm, D. How I learned to stop worrying and love calcineurin. Nat Neurosci 11, 527–528 (2008). https://doi.org/10.1038/nn0508-527

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0508-527

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing