SFRPs are endogenous inhibitors of Wnt signaling. New work shows that, independently of its interaction with Wnts, SFRP1 can act as a repulsive guidance molecule for retinal axons on their way to the tectum, signaling through the receptor Fz2.
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Drescher, U. A no-Wnt situation: SFRPs as axon guidance molecules. Nat Neurosci 8, 1281–1282 (2005). https://doi.org/10.1038/nn1005-1281
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DOI: https://doi.org/10.1038/nn1005-1281
