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Nanobiotechnology

Building a basic nanomachine

Attaching certain protein fragments that are found in the nuclear pore complex onto a solid-state nanopore mimics important aspects of the selective transport of molecules and proteins that occurs in real cells.

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Figure 1: Real NPC structure and the minimalist NPC-like device.

References

  1. Kowalczyk, S. W. et al. Nature Nanotech. 6, 433–438 (2011).

    Article  CAS  Google Scholar 

  2. Denning, D. P., Patel, S. S., Uversky, V., Fink, A. L. & Rexach, M. Proc. Natl Acad. Sci. USA 100, 2450–2455 (2003).

    Article  CAS  Google Scholar 

  3. Lim, R. Y. H. et al. Science 318, 640–643 (2007).

    Article  CAS  Google Scholar 

  4. Frey, S. & Gorlich, D. Cell 130, 512–523 (2007).

    Article  CAS  Google Scholar 

  5. Alber, F. et al. Nature 450, 695–701 (2007).

    Article  CAS  Google Scholar 

  6. Tetenbaum-Novatt, J. & Rout, M. Cold Spring Harb. Symp. Quant. Biol. 75, 567–584 (2010).

    Article  CAS  Google Scholar 

  7. Yang, W., Gelles, J. & Musser, S. M. Proc. Natl Acad. Sci. USA 101, 12887–12892 (2004).

    Article  CAS  Google Scholar 

  8. Dange, T., Grünwald, D., Grünwald, A., Peters, R. & Kubitscheck, U. J. Cell Biol. 183, 77 (2008).

    Article  CAS  Google Scholar 

  9. Jovanovic-Talisman, T. et al. Nature 457, 1023–1027 (2008).

    Article  Google Scholar 

  10. Caspi, Y., Zbaida, D., Cohen, H. & Elbaum, M. Nano Lett. 8, 3728–3734 (2008).

    Article  CAS  Google Scholar 

  11. Kohli, P. et al. Science 305, 984–986 (2004).

    Article  CAS  Google Scholar 

  12. Zilman, A. Biophys. J. 96, 1235–1248 (2009).

    Article  CAS  Google Scholar 

  13. Firnkes, M. et al. Nano. Lett. 10, 2162–2167 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Tijana Jovanovic-Talisman or Anton Zilman.

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Jovanovic-Talisman, T., Zilman, A. Building a basic nanomachine. Nature Nanotech 6, 397–398 (2011). https://doi.org/10.1038/nnano.2011.108

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