Figure 1
Schematic of closed-loop DBS control. A change in psychiatric symptoms (likely a dimensional construct such as negative mood, over-generalized fear or hyper-arousal) leads to a stereotyped change in neural activity. This is detected by a neural decoding algorithm, which automatically adjusts brain stimulation parameters according to a pre-defined transfer function. The resulting change decreases the symptom level, which stabilizes the system in a homeostatic loop.
