Abstract
Hereditary non-polyposis colorectal cancer is almost always associated with microsatellite instability, so what is the best way to identify the disorder at an early-stage, and what should the next step be in preventing the development of colorectal cancer? Different clinical and molecular diagnostic guidelines have recently been proposed in the context of recent scientific advances, but how are these criteria interpreted and modified across the world?
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Acknowledgements
The authors would like to acknowledge the participants of the National Cancer Institute Diagnostic Criteria for Hereditary non-Polyposis Colorectal Cancer and Microsatellite Instability meeting, which led to the development and publication (reference 6) of the revised Bethesda guidelines.
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Umar, A., Risinger, J., Hawk, E. et al. Testing guidelines for hereditary non-polyposis colorectal cancer. Nat Rev Cancer 4, 153–158 (2004). https://doi.org/10.1038/nrc1278
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DOI: https://doi.org/10.1038/nrc1278
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