Finnish women <60 years old have an increased risk of death from cardiac events or stroke within a year of stopping hormone-replacement therapy (HRT), compared with women who have not had HRT and with those on current therapy. The safety of the practice of annual discontinuation of HRT should be questioned.
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Lobo, R. Don't be so quick to stop hormone-replacement therapy. Nat Rev Endocrinol 12, 11–13 (2016). https://doi.org/10.1038/nrendo.2015.195
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DOI: https://doi.org/10.1038/nrendo.2015.195
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