The selective, chloride channel 2 activator, lubiprostone, facilitates intestinal-fluid secretion and stimulates gastrointestinal motility. These effects increase stool frequency and improve abdominal discomfort for patients with constipation-predominant IBS, which makes lubiprostone the newest addition to the treatment armamentarium for these patients. Findings from a new, pivotal, phase III study by Drossman and colleagues support the use of lubiprostone in such patients.
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Crowell, M. Lubiprostone: trials and tribulations. Nat Rev Gastroenterol Hepatol 6, 259–260 (2009). https://doi.org/10.1038/nrgastro.2009.62
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DOI: https://doi.org/10.1038/nrgastro.2009.62
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