Research has highlighted the importance of the stroma in pancreatic cancer, in particular the role of complex interactions between cancer and stromal cells. A new study describes a novel mechanism by which stromal pathways can be modulated to inhibit tumour growth. The findings support the concept that a multipronged therapeutic approach targeting pancreatic cancer cells and cancer stroma could improve clinical outcomes for this disease.
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References
Apte, M. V. et al. Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29, 179–187 (2004).
Wörmann, S. M. et al. Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2016.03.010 (2016).
Apte, M. V., Pirola, R. C. & Wilson, J. S. in Stellate Cells in Health and Disease 1st edn Vol. 1 (eds Gandhi, C. S. & Pinzani, M.) 271–299 (Elsevier, 2015).
Wang, L. M. et al. The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget 7, 4183–4194 (2016).
Pothula, S. P. et al. Key role of pancreatic stellate cells in pancreatic cancer. Cancer Lett. http://dx.doi.org/10.1016/j.canlet.2015.10.035 (2015).
Zhang, H. et al. Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells. Oncotarget 6, 3085–3097 (2015).
Cabrera, M. C. et al. Human pancreatic cancer-associated stellate cells remain activated after in vivo chemoradiation. Front. Oncol. 4, 102 (2014).
Rhim, A. D. et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735–747 (2014).
Ozdemir, B. C. et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25, 719–734 (2014).
Pothula, S. P. et al. Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer. Br. J. Cancer 114, 269–280 (2016).
Acknowledgements
The authors acknowledge the support of grant funding from the National Health and Medical Research Council of Australia and the New South Wales Cancer Council.
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Apte, M., Wilson, J. A multipronged approach to pancreatic cancer treatment. Nat Rev Gastroenterol Hepatol 13, 385–387 (2016). https://doi.org/10.1038/nrgastro.2016.75
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DOI: https://doi.org/10.1038/nrgastro.2016.75
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