Abstract
Activation of most major innate immune signalling cascades relies on the detection of microorganisms or their associated danger signals by host pattern recognition molecules. A flurry of recent studies has now uncovered a role for host translation inhibition in innate immune surveillance and the detection of bacterial pathogens. Here, we present the main findings from these studies and discuss whether translation inhibition is an alarm signal that directly drives innate immune responses to bacterial pathogens, or rather one component of a more general metabolic stress response to infection.
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Acknowledgements
The authors thank E. R. Troemel and D. J. Philpott for critical reading of the manuscript. Research in the B.L. laboratory is supported by grants from the European Research Council and by the Swiss National Science Foundation (grant 3100A0-12079/1). Research in the S.E.G. laboratory is supported by grants from the Canadian Institutes of Health Research, the Burroughs Wellcome Fund and the Crohn's and Colitis Foundation of Canada.
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Lemaitre, B., Girardin, S. Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens. Nat Rev Microbiol 11, 365–369 (2013). https://doi.org/10.1038/nrmicro3029
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DOI: https://doi.org/10.1038/nrmicro3029
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