Oligoclonal IgG bands are present in the cerebrospinal fluid of most patients with multiple sclerosis (MS) and constitute a useful tool to enable accurate diagnosis. A recent meta-analysis has explored the precise prevalence of these antibodies in MS and their possible relationship with geographical location and patient outcome.
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References
Polman, C. H. et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 69, 292–302 (2011).
Dobson, R., Ramagopalan, S., Davis, A. & Giovannoni, G. Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude. J. Neurol. Neurosurg. Psychiatry http://dx.doi.org/10.1136/jnnp-2012-304695.
Masjuan, J. et al. Clinically isolated syndromes. A new oligoclonal band test accurately predicts conversion to MS. Neurology 66, 576–578 (2006).
Tumani, H. et al. Revised McDonald criteria: the persisting importance of cerebrospinal fluid analysis. Ann. Neurol. 70, 520 (2011).
Selchen, D. et al. MS, MRI, and the 2010 McDonald criteria: a Canadian expert commentary. Neurology 79 (Suppl. 2), S1–S15 (2012).
Solomon, A. J., Klein, E. P. & Bourdette, D. “Undiagnosing” multiple sclerosis. The challenge of misdiagnosis in MS. Neurology 78, 1986–1991 (2012).
Villar, L. M. et al. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J. Clin. Invest. 115, 187–194 (2005).
Brettschneider, J. et al. IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome. PLoS ONE 4, e7638 (2009).
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J. C. Álvarez-Cermeño and L. M. Villar received honoraria for speaking and support for research from Biogen Idec, Bayer-Schering, Merck Serono, Teva, and Novartis. J. C. Álvarez-Cermeño received honoraria for consuntancy from Biogen Idec, Merck Serono, Genzyme, and Novartis.
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Álvarez-Cermeño, J., Villar, L. Oligoclonal bands—a useful tool to avoid MS misdiagnosis. Nat Rev Neurol 9, 303–304 (2013). https://doi.org/10.1038/nrneurol.2013.74
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DOI: https://doi.org/10.1038/nrneurol.2013.74
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