Preventive strategies for Alzheimer disease (AD) will depend on the identification of modifiable risk factors for this disorder. A new study has quantified the relative contributions of seven major risk factors for AD, and concludes that around one-third of AD cases are likely to be preventable.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Associations between vascular risk factors and subsequent Alzheimer’s disease in older adults
Alzheimer's Research & Therapy Open Access 26 September 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K. & Brayne, C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 13, 788–794 (2014).
Barnes, D. E. & Yaffe, K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 10, 819–828 (2011).
Matthews, F. E. et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet 382, 1405–1412 (2013).
Qiu, C., von Strauss, E., Bäckman, L., Winblad, B. & Fratiglioni, L. Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology 80, 1888–1894 (2013).
Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet http://dx.doi.org/10.1016/S0140–6736(14)60460–8.
IDF Diabetes Atlas, 6th edn. International Diabetes Federation [online], (2013).
Solomon, A. et al. Advances in the prevention of Alzheimer's disease and dementia. J. Intern. Med. 275, 229–250 (2014).
Kivipelto, M. et al. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 5, 735–741 (2006).
Kivipelto, M. et al. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress. Alzheimers Dement. 9, 657–665 (2013).
Smith, A. D. & Yaffe, K. Dementia (including Alzheimer's disease) can be prevented: statement supported by international experts. J. Alzheimers Dis. 38, 699–703 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Kivipelto, M., Mangialasche, F. To what extent can Alzheimer disease be prevented?. Nat Rev Neurol 10, 552–553 (2014). https://doi.org/10.1038/nrneurol.2014.170
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2014.170
This article is cited by
-
Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank
Nature Human Behaviour (2023)
-
Mediation of the APOE associations with Alzheimer’s and coronary heart diseases through body mass index and lipids
GeroScience (2022)
-
Associations between vascular risk factors and subsequent Alzheimer’s disease in older adults
Alzheimer's Research & Therapy (2020)
-
Präventionsstrategien gegen Demenz
Zeitschrift fĂĽr Gerontologie und Geriatrie (2017)
-
The Role of Copper in Human Diet and Risk of Dementia
Current Nutrition Reports (2015)