A randomized placebo-controlled phase III trial of adjuvanted herpes zoster subunit vaccine has shown a substantial improvement in vaccine efficacy in adults aged ≥70 years compared with the currently used, live attenuated vaccine. The finding has profound implications for reducing illness burden, although the duration of vaccine protection needs further evaluation.
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References
Cunningham, A. L. et al. Efficacy of herpes zoster subunit vaccine in adults 70 years of age or older. N. Engl. J. Med. 375, 1019–1032 (2016).
Lal, H. et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N. Engl. J. Med. 372, 2087–2096 (2015).
Cook, S. J. & Flaherty, D. K. Review of the persistence of herpes zoster vaccine efficacy in clinical trials. Clin. Ther. 37, 2388–2397 (2015).
Oxman, M. N. et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N. Engl. J. Med. 352, 2271–2284 (2005).
Schmader, K. E. et al. Efficacy, safety and tolerability of herpes zoster vaccine in persons aged 50–59 years. Clin. Infect. Dis. 54, 922–928 (2012).
Levin, M. Immune senescence and vaccines to prevent herpes zoster in older persons. Curr. Opin. Immunol. 24, 494–500 (2012).
Macaulay, R., Akbar, A. N. & Henson, S. M. The role of the T cell in age-related inflammation. Age (Dordr.) 35, 563–572 (2013).
Hope-Simpson, R. E. The nature of herpes zoster: a long-term study and a new hypothesis. Proc. R. Soc. Med. 58, 9–20 (1965).
Forbes, H. J. et al. Quantification of risk factors for postherpetic neuralgia in herpes zoster patients: a cohort study. Neurology 87, 94–102 (2016).
Hobbelen, P. H. F., Stowe, J., Amirthalingam, G., Miller, L. & van Hoek, A.-J. The burden of hospitalisation for varicella and herpes zoster in England from 2004 to 2013. J. Infect. 73, 241–253 (2016).
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Warren-Gash, C., Breuer, J. A new herpes zoster subunit vaccine for older adults. Nat Rev Neurol 12, 682–683 (2016). https://doi.org/10.1038/nrneurol.2016.168
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DOI: https://doi.org/10.1038/nrneurol.2016.168