Mapping of ribonucleotides to single-nucleotide resolution in yeast genomes provides new insight into the enzymology of DNA replication.
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References
Kunkel, T.A. & Burgers, P.M. Nat. Struct. Mol. Biol. 21, 649–651 (2014).
Joyce, C.M. Proc. Natl. Acad. Sci. USA 94, 1619–1622 (1997).
Kim, N. et al. Science 332, 1561–1564 (2011).
Nick McElhinny, S.A. et al. Nat. Chem. Biol. 6, 774–781 (2010).
Nick McElhinny, S.A. et al. Proc. Natl. Acad. Sci. USA 107, 4949–4954 (2010).
Potenski, C.J., Niu, H., Sung, P. & Klein, H.L. Nature 511, 251–254 (2014).
Clausen, A.R. et al. Nat. Struct. Mol. Biol. 22, 185–191 (2015).
Daigaku, Y. et al. Nat. Struct. Mol. Biol. 22, 192–198 (2015).
Reijns, M.A. et al. Nature, doi:10.1038/nature14183 (26 January 2015).
Koh, K.D., Balachander, S., Hesselberth, J.R. & Storici, F. Nat. Methods 12, 251–257 (2015).
Williams, J.S. & Kunkel, T.A. DNA Repair (Amst.) 19, 27–37 (2014).
Cerritelli, S.M. & Crouch, R.J. FEBS J. 276, 1494–1505 (2009).
Sparks, J.L. et al. Mol. Cell 47, 980–986 (2012).
Remus, B.S., Jacewicz, A. & Shuman, S. RNA 20, 1697–1705 (2014).
Schutz, K., Hesselberth, J.R. & Fields, S. RNA 16, 621–631 (2010).
Reijns, M.A. et al. Cell 149, 1008–1022 (2012).
Feng, W. & D'Urso, G. Mol. Cell. Biol. 21, 4495–4504 (2001).
Kesti, T., Flick, K., Keranen, S., Syvaoja, J.E. & Wittenberg, C. Mol. Cell 3, 679–685 (1999).
Smith, D.J. & Whitehouse, I. Nature 483, 434–438 (2012).
Pavlov, Y.I. et al. Curr. Biol. 16, 202–207 (2006).
House, N.C., Koch, M.R. & Freudenreich, C.H. Front. Genet. 5, 296 (2014).
Sayrac, S., Vengrova, S., Godfrey, E.L. & Dalgaard, J.Z. PLoS Genet. 7, e1001328 (2011).
Ghodgaonkar, M.M. et al. Mol. Cell 50, 323–332 (2013).
Lujan, S.A., Williams, J.S., Clausen, A.R., Clark, A.B. & Kunkel, T.A. Mol. Cell 50, 437–443 (2013).
Crow, Y.J. et al. Nat. Genet. 38, 910–916 (2006).
Gunther, C. et al. J. Clin. Invest. 125, 413–424 (2015).
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Jinks-Robertson, S., Klein, H. Ribonucleotides in DNA: hidden in plain sight. Nat Struct Mol Biol 22, 176–178 (2015). https://doi.org/10.1038/nsmb.2981
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DOI: https://doi.org/10.1038/nsmb.2981
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