Determining the molecular mechanisms responsible for trinucleotide DNA repeat expansions is critical, as such expansions underlie many neuromuscular and neurodegenerative disorders. Mirkin and colleagues now propose that large-scale expansions of trinucleotide repeats can be generated by DNA-break-induced replication.
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This work was supported by NIGMS (grant GM084242).
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Kramara, J., Osia, B. & Malkova, A. Break-induced replication: an unhealthy choice for stress relief?. Nat Struct Mol Biol 24, 11–12 (2017). https://doi.org/10.1038/nsmb.3361
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DOI: https://doi.org/10.1038/nsmb.3361