Intermediate conformations of the Hsp90 ATPase cycle have been identified in solution by fluorescence resonance energy transfer, and the impact of nucleotides and of modulatory cochaperones has been visualized in real time.
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References
Neckers, L. Trends Mol. Med. 8, S55–S61 (2002).
Pearl, L.H. & Prodromou, C. Annu. Rev. Biochem. 75, 271–294 (2006).
Wandinger, S.K., Richter, K. & Buchner, J. J. Biol. Chem. 283, 18473–18477 (2008).
Ali, M.M. et al. Nature 440, 1013–1017 (2006).
Phillips, J.J. et al. J. Mol. Biol. 372, 1189–1203 (2007).
Shiau, A.K., Harris, S.F., Southworth, D.R. & Agard, D.A. Cell 127, 329–340 (2006).
Southworth, D.R. & Agard, D.A. Mol. Cell 32, 631–640 (2008).
Vaughan, C.K. et al. Mol. Cell 23, 697–707 (2006).
Meyer, P. et al. Mol. Cell 11, 647–658 (2003).
Bron, P. et al. Biol. Cell 100, 413–425 (2008).
Prodromou, C. et al. EMBO J. 19, 4383–4392 (2000).
McLaughlin, S.H., Smith, H.W. & Jackson, S.E. J. Mol. Biol. 315, 787–798 (2002).
Graf, C., Stankiewicz, M., Kramer, G. & Mayer, M.P. EMBO J. published online, doi:10.1038/emboj.2008.306 (22 January 2009).
Mickler, M., Hessling, M., Ratzke, C., Buchner, J. & Hugel, T. Nat. Struct. Mol. Biol. 16, 281–286 (2009).
Hessling, M., Richter, K. & Buchner, J. Nat. Struct. Mol. Biol. 16, 287–293 (2009).
Krukenberg, K.A., Forster, F., Rice, L.M., Sali, A. & Agard, D.A. Structure 16, 755–765 (2008).
Eiseman, J.L. et al. Cancer Chemother. Pharmacol. 55, 21–32 (2005).
Chiosis, G. & Neckers, L. ACS Chem. Biol. 1, 279–284 (2006).
Kamal, A. et al. Nature 425, 407–410 (2003).
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Neckers, L., Tsutsumi, S. & Mollapour, M. Visualizing the twists and turns of a molecular chaperone. Nat Struct Mol Biol 16, 235–236 (2009). https://doi.org/10.1038/nsmb0309-235
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DOI: https://doi.org/10.1038/nsmb0309-235